RESEARCH SNAPSHOTS
See for yourself what we are doing!
|
MftR regulates mycofactocin biosynthesis
Congrats to Aigera for determining how and when mycofactocin (MFT) is regulated. She recently published on the regulator, MftR, which controls MFT biosynthesis and is turned on by oleoyl-CoA.
TvgB forms cyclopropylglycine from valine on a unique peptide.
Congrats to Anastasiia, the lab, and company for showing novel rSAM chemistry! She showed that the rSAM enzyme TvgB transforms valine to cyclopropylglycine on the peptide TvgA - and it does it up to 9 times! This is unprecedented in the rSAM RiPP field.
|
|
OUR PASSION
We love peptide modification pathways! We are deeply interested in understanding how peptides can undergo post-translational modifications and end up being bacterial vitamins, antibiotics, and other important biological molecules. Specifically, we are investigating the mycofactocin biosynthetic pathway, a seemingly important molecule for pathogens such as M. tuberculosis, M. ulcerans, and M. avium.