RESEARCH SNAPSHOTS
See for yourself what we are doing!
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The Ongoing Story of MftCMftC catalyzes the two-step modification of the peptide MftA to form a moiety we dubbed AHDP. However, how it catalyzes this chemistry is still unknown. Recently, with the help of outstanding collaborators, we found that MftC contains three [4Fe-4S] clusters that are all required for catalysis (Biochemistry 2019). Future work will focus on how the structure influences chemistry.
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OUR PASSION
We love peptide modification pathways! We are deeply interested in understanding how peptides can undergo post-translational modifications and end up being bacterial vitamins, antibiotics, and other important biological molecules. Specifically, we are investigating the mycofactocin biosynthetic pathway, a seemingly important molecule for pathogens such as M. tuberculosis, M. ulcerans, and M. avium.