The Ongoing Story of MftC
MftC catalyzes the two-step modification of the peptide MftA to form a moiety we dubbed AHDP. However, how it catalyzes this chemistry is still unknown. Recently, with the help of outstanding collaborators, we found that MftC contains three [4Fe-4S] clusters that are all required for catalysis (Biochemistry 2019). Future work will focus on how the structure influences chemistry.