RESEARCH SNAPSHOTS
See for yourself what we are doing!
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The new kid on the block - MftDJust recently we demonstrated that MftD oxidizes the small molecule intermediate of mycofactocin, AHDP, to form what we call premycofactocin. This molecule, shown above, contains a biologically active redox center that is able to serve as an electron acceptor for carveol dehydrogenase. Finally we know that mycofactocin is a redox cofactor!
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OUR PASSION
We love peptide modification pathways! We are deeply interested in understanding how peptides can undergo post-translational modifications and end up being bacterial vitamins, antibiotics, and other important biological molecules. Specifically, we are investigating the mycofactocin biosynthetic pathway, a seemingly important molecule for pathogens such as M. tuberculosis, M. ulcerans, and M. avium.