MftE catalyzes the selective hydrolysis of MftA*, the major product from MftC (JBC 2017). The hydrolysis of MftA* results in the newly discovered molecule 3-amino-5-[(p-hydroxyphenyl) methyl]-4,4-dimethyl-2-pyrrolidinone or what we call AHDP (Biochemistry 2018).
We love peptide modification pathways! We are deeply interested in understanding how peptides can undergo post-translational modifications and end up being bacterial vitamins, antibiotics, and other important biological molecules. Specifically, we are investigating the mycofactocin biosynthetic pathway, a seemingly important molecule for pathogens such as M. tuberculosis, M. ulcerans, and M. avium.