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Latham Lab

University of Denver
Department of Chemistry and Biochemistry
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RESEARCH SNAPSHOTS

See for yourself what we are doing!
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MftR regulates mycofactocin biosynthesis
​Congrats to Aigera for determining how and when mycofactocin (MFT) is regulated. She recently published on the regulator, MftR, which controls MFT biosynthesis and is turned on by oleoyl-CoA. 
TvgB forms cyclopropylglycine from valine on a unique peptide. ​
Congrats to Anastasiia, the lab, and company for showing novel rSAM chemistry! She showed that the rSAM enzyme TvgB transforms valine to cyclopropylglycine on the peptide TvgA - and it does it up to 9 times! This is unprecedented in the rSAM RiPP field. 

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OUR PASSION

We love peptide modification pathways!  We are deeply interested in understanding how peptides can undergo post-translational modifications and end up being bacterial vitamins, antibiotics, and other important biological molecules.  Specifically, we are investigating the mycofactocin biosynthetic pathway, a seemingly important molecule for pathogens such as M. tuberculosis, M. ulcerans, and M. avium​.
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  • Research
  • MEET US
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